everytine i play a gun based bethesda game, i always pick some theme to go on which limits my option intentionally.

for example, i played FO4 with pistols/revolvers only with thr luck special stat maxed.

aometimes you can end up having some challenging runs (e.g melee only)

I really like survival mode combined with this mod and some additional QoL stuff

https://www.nexusmods.com/fallout4/mods/14669

I highly suggest giving it a go with some of the lore friendly and difficulty mods available. There’s so much you can do now.